Long-Term Melatonin Use and Heart Risk
Using melatonin for extended periods to address sleep issues may carry unexpected cardiac dangers. Research indicates that chronic melatonin users face nearly double the risk of death and are 3.5 times more likely to be hospitalized due to heart failure.
Study Findings Presented at AHA 2025
A preliminary study showcased at the American Heart Association's Scientific Sessions 2025 revealed that adults with chronic insomnia who took melatonin for a year or longer had a greater likelihood of developing heart failure, being hospitalized for it, and dying from any cause compared to those not using the supplement.
The findings were shared at the AHA's annual meeting, held Nov. 7-10 in New Orleans, a major event for cardiovascular science and clinical research updates.
Melatonin's Role and Usage
Melatonin, a hormone produced by the pineal gland, regulates the sleep-wake cycle by increasing in darkness and decreasing with daylight. Synthetic melatonin, identical to the natural hormone, is commonly used to treat insomnia and jet lag. In the U.S. and many other countries, it is sold over the counter.
However, melatonin supplements are not regulated in the U.S., leading to significant variability in product purity and dosage.
Expert Warnings
Although widely perceived as safe, experts now advise caution regarding long-term melatonin use due to its potential heart risks.
Summary
Extended melatonin use for sleep disorders may increase the risk of heart failure and mortality, urging careful consideration and further research.
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