Common Supplement Shows Concerning Link to Heart Failure

Common Supplement Shows Concerning Link to Heart Failure

New research into a popular sleeping aid has raised concerns about long-term use. An analysis of adults with insomnia, not yet peer-reviewed, found that those prescribed melatonin for more than a year face increased heart risks.

Study Findings

Among over 130,000 adults from multiple countries, long-term melatonin users had an 89% higher risk of heart failure within five years. They were also twice as likely to die from any cause compared to those not prescribed melatonin.

Context and Caution

These findings are preliminary and do not alter current health guidelines. They do not necessarily prove that melatonin causes harmful effects.

The results "suggest that longer-term uses of melatonin need to be studied further to ensure they are safe."

Melatonin is widely regarded as safe for short-term use, generally up to 1 to 2 months, especially by those who are not pregnant or breastfeeding. Research on its effects beyond this period remains limited.

Growing Popularity and Need for Further Research

As melatonin’s popularity increases, some researchers stress the importance of more comprehensive studies on its long-term safety.

The new research was shared at the American Heart Association's Scientific Sessions.

Related Study

Summary: Preliminary data suggest potential heart risks linked to melatonin use beyond one year, highlighting the need for more research on its long-term safety.

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ScienceAlert ScienceAlert — 2025-11-07