Patriots vs. Buccaneers NFL prediction, picks and best bets: New England heads south for big test

Patriots vs. Buccaneers NFL Prediction, Picks, and Best Bets

Get expert predictions, picks, and best bets for the Patriots vs. Buccaneers matchup in NFL Week 10. Analyze odds, key stats, and betting trends before placing your wager.

Matchup Overview

Two surprising and exciting teams face off Sunday afternoon as the New England Patriots visit the Tampa Bay Buccaneers. Tampa Bay's 6-2 record has exceeded expectations despite multiple injuries. Meanwhile, the Patriots have unexpectedly surged to a 7-2 record, leading the AFC East at midseason.

Key Players

Both Drake Maye and Baker Mayfield have appeared in MVP conversations recently, promising an intriguing quarterback duel.

Current Form and Betting Odds

The Buccaneers are slight favorites at home according to top Massachusetts sportsbooks, reflecting their advantage despite recent struggles. Baker Mayfield's MVP campaign has slowed, with only two offensive touchdowns in the last two games. He is completing 58% of his passes and averaging 190 yards per game amid injury challenges affecting him and the team's offensive line and weapons.

"The Buccaneers’ offense has looked bad the last two weeks as Baker Mayfield’s MVP campaign has hit a bump."

Betting Perspective

This game presents an interesting betting scenario due to both teams' strong records but recent offensive difficulties for Tampa Bay. Evaluating the impact of injuries and quarterback performance will be key.

Author's summary: Both teams exceed expectations this season, setting up a pivotal NFL Week 10 clash marked by strong records and injury challenges affecting key offensive players.

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MassLive MassLive — 2025-11-09