NFL Picks and Predictions for Week 6
The NFL season continues with a highly-anticipated slate of games in Week 6. Here are 3 plus-money bets to consider before kickoff.
By Spenser Davis, published on Oct 12, 2025.
Plus-Money Bets for Week 6
Last week's NFL bold predictions went 2-1, with an overall gain of +1.17 units. Since Week 3, the picks in this story have earned 2.16 units.
Week 6 Predictions
This week, we explore 3 bold predictions for the NFL. One of these predictions involves fading the Colts offense, which may not be the wisest choice, but it's worth considering.
Fading the Colts offense is perhaps not the wisest choice, but I think there’s a case for doing so here.
Indianapolis is currently averaging 3.39 points per drive, which would be the highest this century if they maintain this pace all season long.
Author's summary: NFL Week 6 plus-money bets and predictions.